Cluster 1 comprises genes important for skeletal muscle (ACTA1) and muscle function (ACTN1) and includes a crucial gene (AKT1) known to regulate insulin signaling, cell survival, and tumor progression (Table 3), as well as two chaperones: HSPA1A and HSPB1 (heat shock proteins (HSPs)). The gene discussed is HSPA1A; the disease is neoplasm.