Consequently, this observational study is a proof of concept that the use of IL-15 in individuals hospitalized with COVID-19 could improve the antiviral immune response, although this stimulus alone would not be effective in those individuals with unresponsive cells due to immune exhaustion or impaired IL-15R signaling pathway, which is essential in the prevention of exhaustion [71], even when they show lymphocyte counts above the threshold of lymphopenia. This evidence concerns the gene IL15 and COVID-19.