CSF2 and neoplasm: From 2007 to 2015, studies focused on anti-tumor immune mechanisms, as indicated by the high burst strength of keywords such as “dendritic cell”, “colony stimulating factor”, “lymphocyte”, and “regulatory T cell”, etc. From 2015 to 2021, keywords such as “vaccine” and “immune checkpoint inhibitors” have high burst strength, suggesting that these areas are becoming new research hotspots.