VEGFA and neoplasm: This increased expression of VEGF in tumor tissue is the result of many factors, the most important of which is hypoxia, which stabilizes and increases the expression of the transcription factor HIF-1α (Hypoxia-inducible factor-1α), which stimulates the transcription of VEGF, which is secreted, diffuses through the tissue, reaches the endothelial cells and binds to specific receptors on their surface.