Under pathophysiological conditions, ATX causes fibrosis in pulmonary diseases [8,9], disruption in energy homeostasis in diabetes/obesity [10], metastasis in various cancers [11,12,13], endothelial permeability in neurovascular diseases [14,15,16], exacerbation of diseases in atherosclerosis [17], and cardiac inflammation during myocardial infarction [18]. The gene discussed is ENPP2; the disease is obesity due to melanocortin 4 receptor deficiency.