CD4 and neoplasm: We also observed that the most three substantial differences between analysis with combined OVT and anti-CTLA-4 and the analysis with monotherapy of OVT are the measure by of CTLA-4-mediated inhibition on IFN-γ of CD4+ T cells, the tumor killing rate δc by cytokines, and the IFN-γ production rate αy by CD4+ T cells.