TP63 and exstrophy-epispadias complex: Similarly, as described in greater detail below, Shalom-Feuerstein et al. reprogrammed fibroblasts from healthy donors and EEC patients carrying two different point mutations in the DNA binding domain of p63 into iPSC lines and managed to rescue and revert the impaired epithelial differentiation following the application of APR-246 (PRIMA-1MET) [37].