TP63 and limb-mammary syndrome: EEC belongs to a collection of syndromes caused by p63 mutations, including Limb mammary syndrome (LMS), acro-dermato-ungual-lacrimal-tooth syndrome (ADULT), ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC), and Rapp-Hodgkin syndrome (RHS), all presenting with similar/overlapping phenotypes [2].