Early speculation that autophagy was linked to cataract arose when progressive posterior polar/subcapsular cataracts were associated with mutations in CHMP4B (charged multivesicular body protein 4b), a core subunit of the endosomal sorting complex required for transport-III (ESCRT-III) machinery, which is important for cellular membrane remodeling and scission processes, including, but not limited to, autophagy [96,97,98]. Here, CHMP4B is linked to cataract.