FYCO1 and cataract: Since then, FYCO1 mutations have been shown to be a relatively common cause of cataract, causing about 2.2% of reported independently ascertained families, although this can increase dramatically in some isolated populations, accounting for almost 14% of autosomal recessive cataracts in the Pakistani population [112] and 86% of inherited cataracts in the Yakut population of Eastern Siberia [113].