Mast cells are well-recognized initiators of IgE-triggered allergic inflammation and anaphylactic responses via their release of a broad array of mediators, including preformed and granule-stored mediators, newly-synthesized eicosanoids, and pro-inflammatory cytokines, upon binding of antigen (Ag) to Ag-specific IgE bound to the high-affinity IgE receptor (FcεRI) [1,2]. This evidence concerns the gene IGHE and inflammatory response.