Reports on the overexpression of AQP5 in colorectal cancer and in pancreatic cancer were a starting point in the attempt to understand the biochemical mechanism causing a rise in the expression of AQP5 [44,48] In their in vitro studies with the use of the NSCLC cell lines H1299 and 16HBE, Elkhider et al. (2020) showed that downregulation of AQP5 inhibited angiogenesis by decreasing the expression of vascular endothelial growth factor (VEGF) [33]. This evidence concerns the gene AQP5 and colorectal cancer.