IL1R1 and type 1 diabetes mellitus: Evaluation of sCD121a or soluble Interleukin 1 receptor type I (sIL-1R1) using CBA revealed a significant increment of sCD121a in plasma of T1D DR patients compared to healthy controls and in mNPDR compared to healthy controls (p = 0.004 and 0.01, respectively, Figure 2).