It is reasonable to assume that the modified gene expression within the KEGG’s ‘Folate biosynthesis’ pathway, in conjunction with the upregulation of GRK2, could enhance the antinociceptive effect exerted by RTX on TRPV1 in LUTSs associated with exaggerated pain transmission, such as interstitial cystitis [81]. This evidence concerns the gene GRK2 and interstitial cystitis.