Recently, Cav3.1 mRNA regulation in melanoma cells was shown to be associated with PTEN expression, where Cav3.1 mRNA levels were higher in the case of PTEN-compromised vemurafenib-resistant (Vem-R) melanoma cells, and Cav3.1 mRNA levels were lower in Vem-R cells with PTEN overexpression. This evidence concerns the gene CACNA1G and melanoma.