Eissmann and co-authors recently demonstrated a vicious signaling axis between IL-33, MCs, and macrophages to sustain angiogenesis and the growth of gastric cancer: tumor epithelial-derived IL-33 activates MCs to produce a chemotactic cytokine expression signature, which promotes a selective accumulation of tumor-associated macrophages (TAMs) [107]. Here, IL33 is linked to neoplasm.