IL18R1 and cancer: In contrast, Il18r−/− CTLs in PancOVA spheroids, 18 h after the start of the coculture, showed increased average speed that was indicative of increased motility, corroborating our own data on the increased effector function of IL-18R-deficient CTLs when compared to that of WT CTLs (Lutz et al., Cancer Immunology Research, in press).