Researchers found that Wnt5a was overexpressed in tumour stroma in vivo and in vitro, especially M2-like tumour-associated macrophages (TAMs), and Wnt5a induced M2 polarisation of TAMs by regulating CaKMII-ERK1/2-STAT3 pathway-mediated IL-10 secretion [105], enhancing tumour growth, invasion and metastasis of CRC, and recruited macrophages whose infiltration depended on CaMKII-ERK pathway-mediated CCL2 secretion [106]. This evidence concerns the gene STAT3 and neoplasm.