PIGR and inflammatory bowel disease: Negative Wnt regulators Axin2 and RNF43 were strongly downregulated in IBD-CRCs and chromosomal gains at HNF4A, a negative regulator of Wnt-induced epithelial–mesenchymal transition (EMT), were less, which compared to sCRCs, while, polymeric immunoglobulin receptor (PIGR) and Oncostatin M Receptor (OSMR) were dysregulated via epigenetic modifications., which is involved in mucosal immunity.