RNF43 and neoplasm: According TCGA data, in colorectal cancer (CRC; n = 594), using Memorial Sloan Kettering Cancer Center (MSKCC), the largest fraction of sporadic tumours accumulates APC mutations (67%), followed by lower fractions of ring finger protein 43 (RNF43) (8%), β-catenin (6%), and Axin2 (5%) mutations according to frequency of mutation or deep deletion of the Wnt pathway genes [34].