In terms of Fusobacterium nucleatum in CRC carcinogenesis via the Wnt signalling pathway, it has been reported that the F. nucleatum-associated CRC process was modulated by the phospholipid-binding protein Annexin A1, which was upregulated in cancerous cells by binding FadA, a F. nucleatum adhesion molecule, to E-cadherin, resulting in the activation of β-catenin-regulated transcription and an increased expression of transcription factors and the oncogenes c-Myc and Cyclin D1 [51,52]. This evidence concerns the gene CCND1 and colorectal carcinoma.