Neuroligin 1 (NLGN1) promoted APC localisation to the cell membrane, and co-immunoprecipitates with some isoforms of this protein stimulated β-catenin translocation to the nucleus, upregulating mesenchymal markers and Wnt target genes and inducing an “EMT phenotype” in CRC cell lines [143]. The gene discussed is APC; the disease is colorectal carcinoma.