SMYD2 overexpression promoted cell proliferation but also increased the metastatic ability of CRC and may activate the Wnt/β-catenin pathway, as SMYD2 overexpression suppresses the expression of adenomatous polyposis coli 2 (APC2), an inhibitor of the Wnt/β-catenin pathway. The gene discussed is SMYD2; the disease is colorectal carcinoma.