According to clinical, molecular, and pathologic features, mutations of F-box and WD repeat domain-containing 7 (FBXW7), a member of the Dickkopf (DKK) family, result in aberrant cytoplasmic and nuclear β-catenin accumulation, although at a lower rate than CTNNB1-mutated CRC [200]. The gene discussed is FBXW7; the disease is colorectal carcinoma.