CCL2 and neoplasm: TRIM24 was highly expressed in CRC tissues compared to nonneoplastic adjacent tissues; the overexpression of TRIM24 upregulates the expression of vascular endothelial growth factor (VEGF), CCL2/5, and CSF-1 via Wnt/β-catenin signalling to stimulate angiogenesis and recruited TAMs, which promotes CRC tumour growth [114].