Interestingly, KLF4 and SOX4 mRNAs were also upregulated in ARHigh cells compared to ARLow cells (fold change = 1.7, p value = 4.67 × 10−14 and fold change = 1.82, p value = 8.23 × 10−51, respectively [13]), suggesting that, even under standard adherent culture conditions, these genes might be involved in the AR/RUNX1 axis that drives tumor cell fate. Here, KLF4 is linked to neoplasm.