This is in contrast to systemic transgenic CTRP9 overexpression in mice, which protected from diet-induced obesity and metabolic dysfunction by triggering reduced food intake, an increased oxygen consumption rate in part due to enhanced mitochondrial content, increased fatty acid oxidation enzyme expression and chronic AMPK activation in skeletal muscle [9]. The gene discussed is C1QTNF9; the disease is obesity due to melanocortin 4 receptor deficiency.