RHOA and acute lymphoblastic leukemia: In vitro studies further demonstrated that blockade of RHOA with Cethrin could enhance the adhesion of T-ALL cells in vitro, a phenomenon that required the polymerization of actin filaments, thus suggesting that activation of RHOA kinase could promote leukocyte deadhesion by inhibiting integrin- and cytoskeletal-dependent spreading of malignant leukemic cells [129].