Instead, recent whole genome sequencing analyses have found recurrent loss-of-function RHOA hotspot mutations in gastric cancer [11], angioimmunoblastic T cell lymphoma (AITL) [12,13], adult T-cell leukemia/lymphoma (ATLL) [14], Burkitt lymphoma (BL) [15] and diffuse large B-cell lymphoma (DLBCL) [16], which suggests a rather complex picture of RHOA function depending on cancer cell type. This evidence concerns the gene RHOA and diffuse large B-cell lymphoma.