ROR1 and precursor B-cell acute lymphoblastic leukemia: On the other hand, it has been shown that Wnt family member 16 (WNT16b) activates RHOA signaling via a non-canonical WNT pathway and that WNT5a-receptor tyrosine kinase like orphan receptor 1 (ROR1) signaling enhances the proliferation of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells, via RHOA and signal transducer and activator of transcription 3 (STAT3) upregulation [89].