During the testing of germline tumors with mpk-1 RNAi, we found that puf-8(q725); lip-1(zh15) mutants fed OP50 had a lower percentage of tumor formation than that fed HT115, an RNase III-deficient E. coli strain used for feeding RNAi in C. elegans [81,82] (see Figure 5D,F; Supplementary Figure S2). Here, DROSHA is linked to neoplasm.