PRKCA and Myocardial fibrosis: Furthermore, curcumin, through the modulation of the PKC-α and MAPK pathways, decreased the mRNA expression of transcriptional coactivator p300, the accumulation of ECM proteins and controlled oxidative stress and apoptosis in the heart of diabetic rats; this resulted in the attenuation of cardiomyocyte hypertrophy, myocardial fibrosis and left ventricular dysfunction [169].