In accordance with this evidence, our results suggest that since both the phosphorylation of Spastin and the increase in Pin1 expression required for this interaction are induced by EGF treatment, the enhanced EGFR kinase activity in glioblastoma must play a significant role in the orientation of Spastin to actin filaments as a result of its interaction with Pin1. This evidence concerns the gene SPAST and glioblastoma.