ICC analysis showed that the co-localization of endogenous Spastin with actin filaments at the periphery or extended regions of the T98G cells was significantly enhanced upon EGF treatment (Figure 3A,B), which triggers the EGFR kinase activity that has been shown to accelerate angiogenesis and invasion of glioblastoma [30,31]. Here, SPAST is linked to glioblastoma.