It has been pointed out that circulating neutrophils stimulate angiogenesis and enhanced melanoma cell migration toward blood endothelial cells [27], allowing tumor cell invasion; TLR-4 activation in peripheral neutrophils promotes the metastatic spread of melanoma [28]; and neutrophils activated by complement-membrane-attack-complex release neutrophil extracellular traps (NETs), which open the endothelial barrier favoring melanoma cells to reach into the circulation and their systemic spread [29]. Here, TLR4 is linked to melanoma.