A change in cell shapes from cobblestone (epithelial) to spindle-like narrow elongated shape (mesenchymal) has been reported in endometrial cancer cells when treated with TGF-β [65,96,97]; autocrine motility factor (AMF), a tumour-secreted cytokine [103]; IL-6 [65]; and chemokine CCL18 [100] and when co-treated with Receptor activator of nuclear factor (RANK)/Receptor activator of nuclear factor kB ligand (RANKL) and chemokine CCL20 [102]. This evidence concerns the gene IL6 and endometrial cancer.