In a study on human NSCLC, IL-27 was found to induce mesenchymal morphological changes in IL-27-treated NSCLC cells, reduce epithelial markers (E-cadherin and γ-catenin) and EMT-TF Snail, and reciprocally increase mesenchymal marker vimentin predominantly through the Janus kinase-signal transducer and activator of the transcription1 (JAK/STAT1) pathway. This evidence concerns the gene CDH1 and non-small cell lung carcinoma.