The eCBome plays an important role in the maintenance of intestinal homeostasis by regulating permeability and the inflammatory response of the human gut [12,13], as demonstrated by recent studies revealing modifications in the expression of genes encoding the eCBome G protein-coupled receptor 55 (GPR55), cannabinoid receptor 1 and 2 (CB1 and CB2), and the 2-MAG catabolic enzyme monoacylglycerol lipase (MGL), during intestinal inflammation and chronic colitis [14]. The gene discussed is CNR1; the disease is inflammatory response.