IFNB1 and obesity due to melanocortin 4 receptor deficiency: Type 1 interferons are upregulated through obesity-derived metabolic endotoxemia. Lipopolysaccharide (LPS) stimulates the production of IFN-β in mouse adipocytesType II interferon, IFN-γ, is upregulated in obesity due to the influx of IFN-γ-secreting T cells in obese adipose tissuePromotes both a local and systemic inflammatory network between immune cells, adipocytes, and endothelial cells