In this study, we investigated a molecular mechanism underlying cisplatin resistance in two NSCLC cell lines, A549 (p53 wild-type) and H1299 (p53-null) and show that CK2, CD44, and IGFBP-3 are important regulators of cisplatin-induced apoptosis in human lung cancer cells. Here, CD44 is linked to non-small cell lung carcinoma.