IGFBP3 and lung cancer: Our previous studies showed that IGFBP-3 binds HA via the 18-residue basic domain, amino acid residues 215–232 (215-KKGFYKKKQCRPSKGRKR-232) in the C-terminal region of the protein, abolishing HA-CD44 interactions, and decreasing A549 lung cancer cell viability [50].