AKT1 and breast cancer: Our finding that serum and E2-induced ERK1/2 and Akt phosphorylation was inhibited in LEC + MCF-7 spheroids overexpressing miR193a-3p, as well as in LECs treated with condition medium from miR193a-3p transfected MCF-7 cells, suggests that miR193a-3p not only inhibits ERK1/2 and Akt directly but also abrogates the release of ERK and Akt activating proangiogenic factors secreted by BC cells.