ARHGAP11B and microcephaly: This limitation was encountered in an attempt to study hominin encephalisation using HGCA2.0, where ARHGAP11B was selected as the ideal driver gene, as it derived from partial duplication of ARHGAP11A after humans and chimpanzees split [149], promotes basal progenitor amplification and neocortex expansion [150], and its deletion may cause microcephaly [151].