In addition to the gene expression variations, we also observed a slightly higher rate of somatic mutations in these histone acetylation regulators in the TCGA gliomas compared to other epigenetic categories; KAT6B was the only gene containing the same mutation (T1203Rfs*21) at a single position in more than one case (four cases), but no mutated genes were found in “histone phosphorylation”, “reader”, or “chromatin remodeling” categories (Figure 1B). Here, KAT6B is linked to central nervous system cancer.