Interestingly, the mutation of H3-3A (also known as H3F3A) in pediatric high-grade gliomas interferes with the activity of EZH2 methyltransferase/PRC2 complex, leading to an overall decrease in the levels of H3K27me3 concomitant to an increase in H3K27ac [59]; the observation for such hyperacetylation was extended to other histone lysines [60]. The gene discussed is H3-3A; the disease is central nervous system cancer.