FGFR2 and neoplasm: Few studies have investigated the molecular distinction between the different anatomical localizations of the tumor: IDH, EPHA2, BAP1 mutations, and FGFR2 fusions are more common in iCCA, whereas extrahepatic tumors are mainly reported in PRKACA and PRKACB fusions [31], as well as ELF3 and ARID1B mutations [32].