A set of molecules associated with BBB permeability (MMP-2, MMP-9, S100B), restoration (TIMP-1, TIMP-2, TSP-2), neuroinflammation (CCL-2), and endothelial activation (ICAM-1, P-sel) that are affected in epilepsy and can be measured in blood was selected in this study. The gene discussed is TIMP1; the disease is epilepsy.