The serum level of TIMP-1 was higher in children with febrile seizures in course of HHV infection than in children without febrile seizures [94], but lower in children with prolonged febrile seizures with encephalopathy than in children with febrile seizures without encephalopathy, status epilepticus, West syndrome, and control group [95]. This evidence concerns the gene TIMP1 and Encephalopathy.