Immunotherapy (a type of cancer treatment that relies on empowering the body’s own immune cells to fight cancer) has expanded to include: i—immune checkpoint/ligand inhibitors (CTLA-4, PD-1, PD-L1/L2, TIM3, and TIGIT) [1,2,3,4,5,6,7,8,9,10,11,12]; ii—adoptive T-cell transfer therapy (CAR-T, TCR-T, TIL and NK cell) [13,14,15,16,17]; iii—cancer vaccines (T-vec, BCG and Sipuleucel-T) [18,19]; and iv—immunomodulators (thalidomide, lenalidomide and pomalidomide) [20,21,22,23]. Here, CTLA4 is linked to cancer.