In recent years, multiple groups from the USA, Europe, Japan, and China have generated or used B-ALL RNA-seq data to identify new targets of recurring rearrangement (e.g., DUX4, MEF2D, and ZNF384) associated with distinct gene expression profiles and the presence of cases with alterations that phenocopy additional canonical B-ALL drivers, e.g., ETV6::RUNX1-like ALL [107,108]. This evidence concerns the gene DUX4 and acute lymphoblastic leukemia.