In recent years, multiple groups from the USA, Europe, Japan, and China have generated or used B-ALL RNA-seq data to identify new targets of recurring rearrangement (e.g., DUX4, MEF2D, and ZNF384) associated with distinct gene expression profiles and the presence of cases with alterations that phenocopy additional canonical B-ALL drivers, e.g., ETV6::RUNX1-like ALL [107,108]. Here, ETV6 is linked to precursor B-cell acute lymphoblastic leukemia.