The somatic or germline mutations in ETV6 have been shown to contribute to malignancies such as hematologic malignancies, including myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), high-risk B-ALL, early T-cell precursor (ETP) ALL, diffuse large B-cell lymphoma (DLBCL), melanoma, and colon, salivary gland, and breast cancer [18,19]. The gene discussed is ETV6; the disease is acute myeloid leukemia.