Moreover, overexpressing Snail or Slug in Caki-1 cells significantly reversed the inhibitory effect of SPOCK1-KD on expressions of Snail family members and the invasive ability, suggesting that SPOCK1 can drive the Snail family-mediated EMT, resulting in ccRCC metastasis. The gene discussed is SPOCK1; the disease is nonpapillary renal cell carcinoma.