Actually, our results showed that SPOCK1-KD suppressed the EMT progression in ccRCC cells, as evidenced by an increase in the epithelial marker, E-cadherin, and decreases in the mesenchymal markers, N-cadherin and vimentin, as well as the EMT-promoting transcription factors of Snail and Slug. This evidence concerns the gene SNAI2 and nonpapillary renal cell carcinoma.