TP53 and nonpapillary renal cell carcinoma: In addition, we also compared the ccRCC-related transcript factor regulon score between subgroups, which showed that the FDX1low subgroup led to high activation levels of HNF1A and HNF1B, while the FDX1high subgroup displayed high activation levels of FOXE1, TBX18, and TP53 (Figure 5E).