The genome location of CDRs is depicted in Figure 1G, and it should be mentioned that PDHA1 was located at chromosome X. Finally, we used the ssGSEA algorithm to analyze the potential influence of the copper death signature on cancers, which showed that this signature positively correlated with xenobiotic metabolism, oxidative phosphorylation, fatty acid metabolism, and adipogenesis, but negatively correlated with mitotic spindle, G2/M checkpoint, and epithelial mesenchymal transition (Figure 1H). This evidence concerns the gene PDHA1 and cancer.