Since those cells secrete cytokines, such as IL-1β, TNFα, IL-6, IL17, and IFNγ, that are able to spread inflammation towards ASCs and other environmental cells, such as adipocytes, fibroblasts, and endothelial cells, a vicious circle is initiated, leading to the development of a low-grade inflammation within AT and insulin resistance, which spreads towards other metabolic tissues and organs, resulting in metaflammation that is characterized by a chronic low-grade inflammation state induced by metabolic alterations [120]. This evidence concerns the gene IL17A and Insulin resistance.