Even though UM51-PrePodo-hTERT has a hypertriploid karyotype, the cells showed contact inhibition and P53 expression and activation, indicating that the cells had not lost cell-cycle checkpoints or undergone cancerous transformation—even though they share a characteristic of malignant cells, which for the most part bear short telomeres, and telomerase activity is observed in 85–90% of all human cancers [34,51]. Here, TP53 is linked to cancer.