Given the fact that the antibody (# ab191695, Abcam) used in this study may cross-react with A3D and taking into consideration the A3D expression analysis in HNSCC, we strongly believe that the majority of the cytoplasmic and nuclear immunostaining can be considered specific and attributed to the presence of A3B but not A3D. This evidence concerns the gene APOBEC3D and head and neck squamous cell carcinoma.