Given the fact that the antibody (# ab191695, Abcam) used in this study may cross-react with A3D and taking into consideration the A3D expression analysis in HNSCC, we strongly believe that the majority of the cytoplasmic and nuclear immunostaining can be considered specific and attributed to the presence of A3B but not A3D. Here, APOBEC3B is linked to head and neck squamous cell carcinoma.