DHX58 and COVID-19: Although pathogenesis of COVID-19 sequela is still far from entire comprehension, it is generally accepted that antiviral protection is activated as a result of viral PARPs recognition by various variants of body pattern-recognizing receptors (PRRs): Toll-like receptors (TLRs), RIG-I-like receptors (RLR) and the cytoplasmic proteins family receptor involved in caspase activation (NALP), in ensemble causing involvement of both paleo- and neo- immunity components and resulting in the development of inflammation [29,30,31].