Del Gobbo et al. [36], in a study published in 2018 with 303 participants with MTHFR mutations and IUGR, further examined the placentas in order to determine the presence of altered DNA and did not find an association between MTHFR 1298CC genotype and IUGR, but found only a tendency to higher MTHFR 677TT in IUGR. Here, MTHFR is linked to fetal growth restriction.