The findings of the univariate analysis indicated that hypertension (p = 0.026), a lower albumin level (p = 0.002), a higher AFP level (p = 0.035), a lower creatinine level (p = 0.018), and a higher baseline eGFR (p = 0.005) were associated with a large eGFR decline. This evidence concerns the gene AFP and Hypertension.