Peyronnet et al. [25]: a prospective single-center cohort study evaluating the predictive value of NGF, PGE2, BDNF, matrix metalloproteinase 2 (MMP-2), TIMP-2 and TGF-β1 for adverse urodynamic parameters and for upper urinary tract damage in NLUTD patients due to spina bifida (n = 40). This evidence concerns the gene TIMP2 and spina bifida.