Besides, the amount and activity of dipeptidyl peptidase IV (DPPIV/CD26) in urinary microvesicles derived from proximal tubule cells has been shown to correlate with the progression of DN in type 2 DM patients, implying an early tubular impairment, which may be considered an early marker of kidney damage even before the onset of albuminuria [47]. This evidence concerns the gene DPP4 and liver dysplastic nodule.