In a rat model of ischemia/reperfusion injury (IRI), urinary AQP1 and AQP2-containing EVs were reduced, most likely due to impaired trafficking and expression of these proteins in renal tubule epithelial cells [134], confirming previous findings of decreased abundance of AQP1 in kidney transplant recipients in the immediate postoperative days [135]. This evidence concerns the gene AQP1 and ischemia reperfusion injury.