KMT2C and metabolic disease: MLL3 is a critical H3 lysine 4 (H3K4) methyltransferase (H3K4MT) for peroxisome proliferator-activated receptor (PPAR)-dependent adipogenesis, raising the possibility that specific agonists/antagonists of MLL3/4 H3K4MT activity could be useful for treating a variety of metabolic disorders [55].