HCs: healthy controls; MN: membranous nephropathy; MCNS: minimal change nephrotic syndrome; CCL2; chemokine (C-C motif) ligand 2; eGFR: estimated glomerular filtration rate; RT-qPCR: real-time quantitative polymerase chain reaction; MCN: minimal change nephropathy; AUC: area under the curve; IgANnp: IgA nephropathy nonprogressors (∆sCr < 10% over 10 years since diagnosis); IgANp: IgA nephropathy progressors (sCr doubled or developed ESKD over 10 years since diagnosis); TMN: thin membrane nephropathy; NGS: next-generation sequencing. The gene discussed is CCL2; the disease is kidney disorder.