In a proteomic quantitative analysis on urine samples from DN patients in advanced disease stages (CKD stages III–V), a panel of three potential proteins was included (protein fragment of alpha-1-microglobulin/bikunin precursor (AMBP), isoform 1 of histone-lysine N-methyltransferase (MLL3), and voltage-dependent anion-selective channel protein 1 (VDAC1)] [53]. This evidence concerns the gene VDAC1 and liver dysplastic nodule.