Two forms of the disease are known, sporadic, occurring in 90% of ALS cases, and familiar, due to mutations in more than 20 genes, including hexanucleotide expansions in chromosome 9 open reading frame 72, superoxide dismutase 1, TAR DNA-binding protein 43, fused in sarcoma and TANK-binding kinase 1 [6,7]. Here, TARDBP is linked to amyotrophic lateral sclerosis.