In this study, we were keen to find the relationship between ADAM33 SNPs and asthma, its severity, and the treatment responsiveness after three months of regular inhaled corticosteroids (ICS) and long-acting beta-agonist (LABA) using dosages based on the GINA guidelines for the management of mild, moderate, and persistent asthma [21,22]. The gene discussed is ADAM33; the disease is asthma.