In the present study, it has been shown for the first time that increased expression levels of the DNMT1 and HCN1 genes in the somatosensory cortex and hippocampus, DNMT1, HCN1, and TH genes in the nucleus accumbens are associated with long-lasting suppression of the occurrence of absence seizures and comorbid depression in the offspring of WAG/Rij rats. Here, DNMT1 is linked to major depressive disorder.