PSI (hazard ratio [HR] = 1.111, 95% CI: 1.047–1.179; p < 0.001) and CURB-65 score (HR = 10.883, 95% CI: 3.231–36.659; p < 0.001) were independent predictors of SCAP after adjusting for laboratory indices such as WBC, NEU and LYM counts, NLR, and IL-6, IL-8 and IL-10 levels. This evidence concerns the gene IL6 and syringocystadenoma papilliferum.