The combination of AnxA1 level and CURB-65 score weakly improved the predictive accuracy of CURB-65 score for SCAP (i.e., from 0.920 to 0.938), but not when combined with PSI, likely due to the high accuracy of PSI-based diagnosis in this cohort. This evidence concerns the gene ANXA1 and syringocystadenoma papilliferum.