With multivariant analysis, age > 65 years (HR = 1.508, 95% CI = 1.032–2.203, p = 0.034), CEA level (HR = 1.895, 95% CI= 1.204–2.982, p= 0.006), tumor size (HR = 2.494, 95% CI= 1.574–3.953, p < 0.001), presence of lymphovascular invasion (HR = 1.742, 95% CI = 1.118–2.714, p = 0.014), and N1 lymph node metastasis (HR = 2.055, 95% CI = 1.282–3.293, p = 0.003) were independent factors. This evidence concerns the gene CEACAM5 and metastatic malignant neoplasm in the lymph nodes.