BDNF and Hyperreflexia: Moreover, an early and progressive increase in training intensity reduced neuropathic pain [34,79] and prevented neurotrophin-mediated hyperexcitability of peripheral injured nerves [53] and hyperreflexia, as shown by the reduction in the facilitation of the monosynaptic H reflex [11] and the early reappearance of the H reflex with increased amplitude after exercise [31].